1,4-Dioxane hydrochloride → 2-amino-2-(4-chlorophenyl)-N-(5-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)acetamide

HRID 82119ノート

反応式

HRID 82119 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:32]C(=O)OC(C)(C)C)[C:9]([NH:11][C:12]2[CH:13]=[N:14][CH:15]=[C:16]([C:18]([C:20]3[C:28]4[CH:27]=[N:26][CH:25]=[N:24][C:23]=4[N:22]([CH:29]([CH3:31])[CH3:30])[CH:21]=3)=[O:19])[CH:17]=2)=[O:10])=[CH:4][CH:3]=1.Cl.O1CCOCC1>>[NH2:32][CH:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)[C:9]([NH:11][C:12]1[CH:13]=[N:14][CH:15]=[C:16]([C:18]([C:20]2[C:28]3[CH:27]=[N:26][CH:25]=[N:24][C:23]=3[N:22]([CH:29]([CH3:31])[CH3:30])[CH:21]=2)=[O:19])[CH:17]=1)=[O:10]

参加物

3

反応物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 70856232tert-butyl (1-(4-chlorophenyl)-2-((5-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)amino)-2-oxoethyl)carbamate

生成物 1

HCID 708179792-amino-2-(4-chlorophenyl)-N-(5-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)acetamide収率 8%

実験手順

To tert-butyl (1-(4-chlorophenyl)-2-((5-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)amino)-2-oxoethyl)carbamate (Preparation 299, 64 mg, 0.11 mmol) was added 4M HCl/dioxane (5 mL) and the reaction stirred at room temperature for 18 hours. The mixture was evaporated in vacuo and purified by preparative reverse phase HPLC to give the title compound as a beige solid in 8% yield, 4 mg.

後処理

  1. customThe mixture was evaporated in vacuo
  2. custompurified by preparative reverse phase HPLC

出典と根拠

ORDレコード
ord-af974f211c1f4c598f549ccae4a71d68
出典データセット
uspto-grants-2014_09
特許番号
US08846698B2

反応ノート

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