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4-Cyanophenylacetic acid → N-[5-(2-Amino-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-pyridin-3-yl]-2-(4-cyano-phenyl)-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Cyanophenylacetic acid | HCID 79587 | — |
| 反応物 | (2-amino-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(5-amino-pyridin-3-yl)-methanone | HCID 70817234 | — |
| 生成物 | N-[5-(2-Amino-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-pyridin-3-yl]-2-(4-cyano-phenyl)-acetamide | HCID 70817957 | — |
反応手順
The title compound was prepared according to the method described for Example 1 using (2-amino-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(5-amino-pyridin-3-yl)-methanone (see Preparation 65) and 4-cyano phenyl acetic acid to afford the title compound as off white solid in 58%, 23 mg.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846698B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-2cfc86e2739b4fc9a520718e8ac0f6d0 |
| 出典メモ | uspto-grants-2014_09 |