L-Alaninol → (2S)-2-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propan-1-ol

HRID 82141

反応式

HRID 82141 の反応式
Cl[C:2]1[C:7]([CH2:8][CH:9]=O)=[C:6]([Cl:11])[N:5]=[CH:4][N:3]=1.[NH2:12][C@@H:13]([CH3:16])[CH2:14][OH:15]>>[Cl:11][C:6]1[C:7]2[CH:8]=[CH:9][N:12]([C@@H:13]([CH3:16])[CH2:14][OH:15])[C:2]=2[N:3]=[CH:4][N:5]=1

参加物

3

反応物 2

HCID 80307L-AlaninolHCID 13989292(4,6-Dichloropyrimidin-5-yl)acetaldehyde

生成物 1

HCID 86672075(2S)-2-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propan-1-ol

実験手順

The title compound was prepared according to the method described for Preparation 1 using (4,6-dichloropyrimidin-5-yl)acetaldehyde and (S)-2-amino-1-propanol to afford the title compound as a cream solid in 98% yield, 10.9 g.

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-0f253aeb3c0e4d318bedf0e3841bf081
出典データセット
uspto-grants-2014_09
特許番号
US08846698B2

関連ノート

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