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HRID 82182作成日：2026年10月25日

(4-Chlorophenyl)acetic acid → 2-(4-chlorophenyl)-N-(5-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)acetamide

https://huagongshe.com/reaction/82182

反応式

関与物質

役割名称HCID仕込み量
反応物(4-Chlorophenyl)acetic acidHCID 15880—
反応物(5-aminopyridin-3-yl)(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanoneHCID 70817536—
生成物2-(4-chlorophenyl)-N-(5-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)acetamideHCID 70817591—

反応手順

The title compound was prepared according to the method described for Examples 73-87 using (5-aminopyridin-3-yl)(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone (Preparation 103) and 4-chlorophenylacetic acid to afford the title compound as a white solid in 66% yield, 223 mg.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08846698B2
出典データセットuspto-grants-2014_09
ORD IDord-4710b3d775d3481694da288f5e57bf63
出典メモuspto-grants-2014_09