Hydrochloric Acid → 2-(1H-indazol-6-yl)acetic acid

HRID 82224

反応式

HRID 82224 の反応式
Cl.[NH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])[CH:9]=2)[CH:4]=[N:3]1>O1CCOCC1>[NH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:11][C:12]([OH:14])=[O:13])[CH:9]=2)[CH:4]=[N:3]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 70817797tert-Butyl 1H-indazol-6-ylacetate

生成物 1

HCID 595093302-(1H-indazol-6-yl)acetic acid収率 100%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

Hydrochloric acid (10 mL, 4 M in 1.4 dioxane) was added to tert-butyl 1H-indazol-6-ylacetate (Preparation 181, 1.00 g, 4.3 mmol) in 1,4 dioxane (5 mL) at 0° C. and the mixture was stirred at room temperature for 16 hours. The mixture was evaporated in vacuo and the residue was triturated with dry ether to afford the title compound as a white solid in 100% yield, 800 mg.

後処理

  1. customThe mixture was evaporated in vacuo
  2. customthe residue was triturated with dry ether

出典と根拠

ORDレコード
ord-3c81c2c5bc02478a93749e62b6b767fe
出典データセット
uspto-grants-2014_09
特許番号
US08846698B2

関連ノート

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