Hydrochloric Acid → 2-(1H-indazol-6-yl)acetic acid
反応式
Cl.[NH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])[CH:9]=2)[CH:4]=[N:3]1>O1CCOCC1>[NH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:11][C:12]([OH:14])=[O:13])[CH:9]=2)[CH:4]=[N:3]1参加物
4
実験手順
Hydrochloric acid (10 mL, 4 M in 1.4 dioxane) was added to tert-butyl 1H-indazol-6-ylacetate (Preparation 181, 1.00 g, 4.3 mmol) in 1,4 dioxane (5 mL) at 0° C. and the mixture was stirred at room temperature for 16 hours. The mixture was evaporated in vacuo and the residue was triturated with dry ether to afford the title compound as a white solid in 100% yield, 800 mg.
後処理
- customThe mixture was evaporated in vacuo
- customthe residue was triturated with dry ether
出典と根拠
- ORDレコード
- ord-3c81c2c5bc02478a93749e62b6b767fe
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846698B2
反応ノート
読み込み中…