Tert-butyl 1H-pyrazolo[4,3-b]pyridin-1-ylacetate → 1H-Pyrazolo[4,3-b]pyridin-1-ylacetic acid
反応式
[N:1]1([CH2:10][C:11]([O:13]C(C)(C)C)=[O:12])[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[N:2]1>Cl>[N:1]1([CH2:10][C:11]([OH:13])=[O:12])[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[N:2]1参加物
3
実験手順
Tert-butyl 1H-pyrazolo[4,3,b]pyridin-1-ylacetate (Preparation 189, 220 mg, 0.944 mmol) was dissolved in HCl (4 mL, 4.0 M in 1,4 dioxane) and stirred under nitrogen at room temperature for 4 hours. The mixture was evaporated in vacuo and the residue was triturated with anhydrous diethyl ether to afford the title compound as an off white solid in 60% yield, 120 mg.
後処理
- customThe mixture was evaporated in vacuo
- customthe residue was triturated with anhydrous diethyl ether
出典と根拠
- ORDレコード
- ord-c31241dba538465da97b64376e8d7cf9
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846698B2
反応ノート
読み込み中…