Hydrochloric Acid → Hydrochloric Acid
反応式
C([O:5][C:6](=[O:18])[CH2:7][N:8]1[CH2:17][C:16]2[N:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH2:10][CH2:9]1)(C)(C)C.[ClH:19]>O1CCOCC1>[ClH:19].[N:15]1[C:16]2[CH2:17][N:8]([CH2:7][C:6]([OH:18])=[O:5])[CH2:9][CH2:10][C:11]=2[CH:12]=[CH:13][CH:14]=1.[ClH:19]参加物
5
実験手順
(5,8-Dihydro-6H-[1,7]naphthyridin-7-yl)-acetic acid tert-butyl ester (Preparation 234, 1.25 g, 5.03 mmol) was treated with 4N HCl in dioxane (25 ml) at room temperature for 2 hours. The mixture was evaporated to dryness in vacuo and the solid residue was triturated with diethyl ether to afford the title compound as white solid in 78% yield (calculated as HCl salt), 900 mg.
後処理
- customThe mixture was evaporated to dryness in vacuo
- customthe solid residue was triturated with diethyl ether
出典と根拠
- ORDレコード
- ord-a887addf18ec438d898b6b222f312670
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846698B2
反応ノート
読み込み中…