Bromine → HCID 178524767、化合物

HRID 82265

反応式

HRID 82265 の反応式
[Br:1]Br.[OH:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][N:5]=1>O>[Br:1][C:12]1[C:4]([OH:3])=[N:5][CH:6]=[C:7]([CH:11]=1)[C:8]([OH:10])=[O:9]

参加物

4

反応物 2

HCID 24408BromineHCID 178418479HCID 178418479、化合物

生成物 1

HCID 178524767HCID 178524767、化合物収率 82%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Bromine (3.6 mL, 70.5 mmol) was added dropwise to a suspension of 6-Hydroxy-nicotinic acid (7 g, 50.32 mmol) in water (70 mL) at 00° C. and the mixture was stirred at room temperature for 4 hours. The precipitated solid was filtered, washed with cold water and dried to get the title compound as off white solid in 82% yield, 9 g.

後処理

  1. filtrationThe precipitated solid was filtered
  2. washwashed with cold water
  3. customdried

出典と根拠

ORDレコード
ord-1169c5edf7c74bc9a8a658c183330218
出典データセット
uspto-grants-2014_09
特許番号
US08846698B2

関連ノート

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