化工社化工社 化学情報印刷レポート · 研究参考用
4-Cyanophenylacetic acid → 2-(4-Cyano-phenyl)-N-{5-[7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-pyridin-3-yl}-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Cyanophenylacetic acid | HCID 79587 | — |
| 反応物 | (5-aminopyridin-3-yl)(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone | HCID 70817536 | — |
| 生成物 | 2-(4-Cyano-phenyl)-N-{5-[7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-pyridin-3-yl}-acetamide | HCID 70817932 | — |
反応手順
The title compound was prepared according to the method described for Example 1 using (5-Amino-pyridin-3-yl)-[7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-methanone (Preparation 103) and 4-cyanophenylacetic acid to afford the title compound as an off-white solid in 71% yield, 235 mg.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846698B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-b4d4244808f84799bf5c9fa1cc61aa78 |
| 出典メモ | uspto-grants-2014_09 |