Methanol → cis-N2-(4-amino-cyclohexylmethyl)-N4,N4-dimethyl-quinazoline-2,4-diamine

反応式

[CH2:1]([O:2][C:3](=[O:4])[NH:10][CH:11]1[CH2:12][CH2:13][CH:14]([CH2:17][NH:18][c:19]2[n:20][c:21]3[cH:22][cH:23][cH:24][cH:25][c:26]3[c:27]([N:29]([CH3:30])[CH3:31])[n:28]2)[CH2:15][CH2:16]1)[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:32]1.[CH3:33][OH:34]>>[NH2:10][CH:11]1[CH2:12][CH2:13][CH:14]([CH2:17][NH:18][c:19]2[n:20][c:21]3[cH:22][cH:23][cH:24][cH:25][c:26]3[c:27]([N:29]([CH3:30])[CH3:31])[n:28]2)[CH2:15][CH2:16]1

参加物

反応物 2

HCID 887Methanol

HCID 68846868trans-{4-[(4-Dimethylamino-quinazolin-2-ylamino)-methyl]-cyclohexyl}-carbamic acid benzyl ester

生成物 1

HCID 68846875cis-N2-(4-amino-cyclohexylmethyl)-N4,N4-dimethyl-quinazoline-2,4-diamine

出典と根拠

ORDレコード: ord-f8a005bca7f742fb826dbc4c35e8e6df
出典データセット: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…