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3-Cyanophenol → Ethyl[4-(3-Hydroxyphenyl)-1H-1,2,3-triazol-1-yl]acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Cyanophenol | HCID 13394 | — |
| 反応物 | Acetic acid, azido-, ethyl ester | HCID 69480 | — |
| 反応物 | Sodium Ascorbate | HCID 23667548 | — |
| 触媒 | Copper Sulfate | HCID 24462 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | tert-Butanol | HCID 6386 | — |
| 生成物 | Ethyl[4-(3-Hydroxyphenyl)-1H-1,2,3-triazol-1-yl]acetate | HCID 70847799 | — |
反応手順
Ethyl azidoacetate (14.9 g, 115 mmol) was dissolved in tert-butanol (200 mL), and 95% 3-hydroxybenzonitrile (13.7 g, 110 mmol) was added. A solution of sodium ascorbate (2.18 g, 11 mmol) in water (100 mL) was added, followed by a 0.3 M solution of copper sulfate under argon. The mixture was stirred at room temperature for 12 hours. The solution was evaporated to dryness in vacuo, the residue was dissolved in EtOAc (100 mL), dried (MgSO4), filtered, evaporated in vacuo to give the title compound as brown crystals in ˜100% (27.7 g) yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846698B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-6ebff5c06872415e8a04b5610978f174 |
| 出典メモ | uspto-grants-2014_09 |