Cesium carbonate → 4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-7-(tetrahydro-furan-2-ylmethoxy)-quinoline

HRID 8244ノート

反応式

HRID 8244 の反応式
[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][O:7]S(C)(=O)=O.[N:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18]1[C:19]([C:26]2[C:35]3[C:30](=[CH:31][C:32](O)=[CH:33][CH:34]=3)[N:29]=[CH:28][CH:27]=2)=[C:20]2[CH2:25][CH2:24][CH2:23][N:21]2[N:22]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C)C=O>[N:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18]1[C:19]([C:26]2[C:35]3[C:30](=[CH:31][C:32]([O:7][CH2:6][CH:2]4[CH2:3][CH2:4][CH2:5][O:1]4)=[CH:33][CH:34]=3)[N:29]=[CH:28][CH:27]=2)=[C:20]2[CH2:25][CH2:24][CH2:23][N:21]2[N:22]=1

参加物

5

反応物 3

HCID 10796Cesium carbonateHCID 266119(Tetrahydrofuran-2-yl)methyl methanesulfonateHCID 1355066154-(2-(Pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-ol

生成物 1

HCID 219925114-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-7-(tetrahydro-furan-2-ylmethoxy)-quinoline

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

A mixture of methanesulfonic acid tetrahydro-furan-2-ylmethyl ester (0.70 g, 3.66 mmol), 4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinolin-7-ol (400 mg, 1.22 mmol), and cesium carbonate (2.38 g, 7.32 mmol) in N,N-dimethylformamide (2.5 mL) is heated at 60° C. for 42 h. The mixture is concentrated in vacuo and the residue chromatographed to yield the title compound, 79 mg (15%), as a tan solid.

後処理

  1. concentrationThe mixture is concentrated in vacuo
  2. customthe residue chromatographed

出典と根拠

ORDレコード
ord-1f71017f179349fd95bf52de87aca6aa
出典データセット
uspto-grants-2006_08
特許番号
US07087626B2

反応ノート

読み込み中…