Thionyl bromide → 4-(Bromomethyl)-2-chloropyridine

HRID 82454

反応式

HRID 82454 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8]O)[CH:5]=[CH:4][N:3]=1.S(Br)([Br:12])=O>ClCCl>[Br:12][CH2:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[CH:7]=1

参加物

4

反応物 2

HCID 68176Thionyl bromideHCID 7062237(2-Chloropyridin-4-yl)methanol

生成物 1

HCID 129548074-(Bromomethyl)-2-chloropyridine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 2-chloropyridine-4-methanol (1.02 g, 7.10 mmol) in 15 mL of dichloromethane was added thionyl bromide (1.77 g, 8.53 mmol) dropwise. After 15 min, the reaction was quenched with saturated aqueous ammonium chloride. The organic solution was washed 2× with water, dried over sodium sulfate, filtered, and concentrated in vacuo to provide 4-(bromomethyl)-2-chloropyridine that gave a mass ion (ES+) of 208.0 for [M+H]+.

後処理

  1. customthe reaction was quenched with saturated aqueous ammonium chloride
  2. washThe organic solution was washed 2× with water
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-17d0cd4dc70248268dec5a69fed8b35c
出典データセット
uspto-grants-2014_09
特許番号
US08846702B2

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