化工社化工社 化学情報印刷レポート · 研究参考用
Methyl iodide → HCID 178503348、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | HCID 178527819 | HCID 178527819 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | HCID 178503348 | HCID 178503348 | 45.8% |
反応手順
To a solution of 1H-imidazo[4,5-b]pyridine-2-thiol (2 g) in acetone (30 mL) were added MeI (0.910 ml) and K2CO3 (5.48 g) at room temperature. After stirring for 10 h, the mixture was concentrated under reduced pressure. The residue was purified by column chromatography (NH-silica gel, eluted with 10%-100% EtOAc in hexane) to give 2-(methylsulfanyl)-3H-imidazo[4,5-b]pyridine (1.0 g) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846713B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-552e96a795fb4545bccf28eb5db15d6d |
| 出典メモ | uspto-grants-2014_09 |