Thiophene-3-carboxylic acid → N-Propyl-N-(3,3,3-trifluoro-2-hydroxy-2-{[(6-methyl-1-phenyl-1H-indazol-4-yl)amino]methyl}propyl)-3-thiophenecarboxamide

反応式

[F:9][C:10]([C:11]([CH2:12][NH:13][c:14]1[c:15]2[cH:16][n:17][n:18](-[c:24]3[cH:25][cH:26][cH:27][cH:28][cH:29]3)[c:19]2[cH:20][c:21]([CH3:23])[cH:22]1)([OH:30])[CH2:31][NH:32][CH2:33][CH2:34][CH3:35])([F:36])[F:37].[s:1]1[cH:2][c:3]([C:6](=[O:7])[OH:8])[cH:4][cH:5]1>>[s:1]1[cH:2][c:3]([C:6](=[O:8])[N:32]([CH2:31][C:11]([C:10]([F:9])([F:36])[F:37])([CH2:12][NH:13][c:14]2[c:15]3[cH:16][n:17][n:18](-[c:24]4[cH:25][cH:26][cH:27][cH:28][cH:29]4)[c:19]3[cH:20][c:21]([CH3:23])[cH:22]2)[OH:30])[CH2:33][CH2:34][CH3:35])[cH:4][cH:5]1

参加物

反応物 2

HCID 6918Thiophene-3-carboxylic acid

HCID 593241271,1,1-Trifluoro-3-[(6-methyl-1-phenyl-1H-indazol-4-yl)amino]-2-[(propylamino)methyl]-2-propanol

生成物 1

HCID 59324164N-Propyl-N-(3,3,3-trifluoro-2-hydroxy-2-{[(6-methyl-1-phenyl-1H-indazol-4-yl)amino]methyl}propyl)-3-thiophenecarboxamide

出典と根拠

ORDレコード: ord-f61122ebaf2443e6a3ee805dab16c86a
出典データセット: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…