7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid → 7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [5-(2-hydroxy-1,1-dimethyl-ethylsulfamoyl)-4-methyl-thiazol-2-yl]-amide

反応式

[F:1][CH:2]([c:3]1[cH:4][c:5](-[c:15]2[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]2)[n:6][c:7]2[n:8]1[n:9][cH:10][c:11]2[C:12](=[O:13])[OH:14])[F:25].[OH:26][CH2:27][C:28]([CH3:29])([CH3:30])[NH:31][S:32](=[O:33])(=[O:34])[c:35]1[c:36]([CH3:41])[n:37][c:38]([NH2:40])[s:39]1>>[F:1][CH:2]([c:3]1[cH:4][c:5](-[c:15]2[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]2)[n:6][c:7]2[n:8]1[n:9][cH:10][c:11]2[C:12](=[O:13])[NH:40][c:38]1[n:37][c:36]([CH3:41])[c:35]([S:32]([NH:31][C:28]([CH2:27][OH:26])([CH3:29])[CH3:30])(=[O:33])=[O:34])[s:39]1)[F:25]