Triacetoxyperiodinane → 3-(7-Bromo-quinolin-4-yl)-2-pyridin-2-yl-5,6-dihydro-pyrrolo[1,2-b]pyrazol-4-one

HRID 8264

反応式

HRID 8264 の反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:12]3[C:16]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=4)=[N:15][N:14]4[CH2:23][CH2:24][CH:25]([OH:26])[C:13]=34)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>ClCCl>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:12]3[C:16]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=4)=[N:15][N:14]4[CH2:23][CH2:24][C:25](=[O:26])[C:13]=34)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 159087TriacetoxyperiodinaneHCID 101795483-(7-bromo-quinolin-4-yl)-2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-4-ol

生成物 1

HCID 102012673-(7-Bromo-quinolin-4-yl)-2-pyridin-2-yl-5,6-dihydro-pyrrolo[1,2-b]pyrazol-4-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 3-(7-bromo-quinolin-4-yl)-2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-4-ol (89.0 mg, 0.22 mmol) in dry dichloromethane (2 mL) is added Dess-Martin periodinane (301.0 mg, 0.71 mmol) and the resulting mixture stirred for 18 h. The reaction mixture is chromatographed on SiO2 (dichloromethane to 20% methanol in dichloromethane) to yield a yellow solid, 78 mg (88%).

後処理

  1. customThe reaction mixture is chromatographed on SiO2 (dichloromethane to 20% methanol in dichloromethane)
  2. customto yield a yellow solid, 78 mg (88%)

出典と根拠

ORDレコード
ord-43ca1bcbc16d469a97431b90b39c825b
出典データセット
uspto-grants-2006_08
特許番号
US07087626B2

関連ノート

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