Potassium Carbonate → 3-[4-(benzyloxy)phenyl]-6-(2,2-difluoroethoxy)-1-ethyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

HRID 82660

反応式

HRID 82660 の反応式
FC(F)(F)S([O:6][CH2:7][CH:8]([F:10])[F:9])(=O)=O.[CH2:13]([O:20][C:21]1[CH:26]=[CH:25][C:24]([N:27]2[C:31]3=[N:32][CH:33]=[C:34](O)[CH:35]=[C:30]3[N:29]([CH2:37][CH3:38])[C:28]2=[O:39])=[CH:23][CH:22]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+].[Cl-].[Cl-].[Ca+2]>CN(C=O)C>[CH2:13]([O:20][C:21]1[CH:22]=[CH:23][C:24]([N:27]2[C:31]3=[N:32][CH:33]=[C:34]([O:6][CH2:7][CH:8]([F:10])[F:9])[CH:35]=[C:30]3[N:29]([CH2:37][CH3:38])[C:28]2=[O:39])=[CH:25][CH:26]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

6

反応物 4

HCID 11430Potassium CarbonateHCID 27740892,2-Difluoroethyl trifluoromethanesulfonateHCID 5284359Calcium ChlorideHCID 585776213-[4-(benzyloxy)phenyl]-1-ethyl-6-hydroxy-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

生成物 1

HCID 585772623-[4-(benzyloxy)phenyl]-6-(2,2-difluoroethoxy)-1-ethyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one収率 85.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

2,2-Difluoroethyl trifluoromethanesulfonate (213 mg) was added to a solution of 3-[4-(benzyloxy)phenyl]-1-ethyl-6-hydroxy-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (300 mg) and potassium carbonate (229 mg) in DMF (5 ml) at room temperature. The mixture was stirred at ambient temperature under a dry atmosphere (CaCl2 tube) for 3 h. The mixture was quenched with water at room temperature and extracted with AcOEt. The organic layer was separated, washed with water and brine, dried over MgSO4 and concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluted with 15%-50% AcOEt in hexane) to give 3-[4-(benzyloxy)phenyl]-6-(2,2-difluoroethoxy)-1-ethyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (301 mg) as colorless oil.

後処理

  1. customThe mixture was quenched with water at room temperature
  2. extractionextracted with AcOEt
  3. customThe organic layer was separated
  4. washwashed with water and brine
  5. dry with materialdried over MgSO4
  6. concentrationconcentrated in vacuo
  7. customThe residue was purified by column chromatography (silica gel, eluted with 15%-50% AcOEt in hexane)

出典と根拠

ORDレコード
ord-2a0c4da4549f412b9b3b8956645e66fe
出典データセット
uspto-grants-2014_09
特許番号
US08846713B2

関連ノート

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