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Diisopropylethylamine → HCID 178526361、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 3-Bromo-4-fluoroaniline | HCID 2779286 | — |
| 反応物 | N-Hydroxy-4-morpholin-4-yl-1,2,5-oxadiazole-3-carboximidoyl chloride | HCID 136335829 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | HCID 178526361 | HCID 178526361 | 48.7% |
反応手順
A solution of N-Hydroxy-4-morpholin-4-yl-1,2,5-oxadiazole-3-carboximidoyl chloride (40 mg, 0.17 mmol) and 3-bromo-4-fluoroaniline (49 mg, 0.26 mmol) in ethanol (1 mL) was treated with a solution of N,N-diisopropylethylamine (45 μL, 0.26 mmol) in acetonitrile (1 mL) and stirred for 62 h. The reaction mixture was purified by preparative HPLC to give the desired product (32 mg, 48%). LCMS for C13H14ClFN5O3 (M+H)+: m/z=386.0, 388.0.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846726B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-c23872f5758d4b33866514e85af99af2 |
| 出典メモ | uspto-grants-2014_09 |