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Dimethylamine → 4-(2-Furyl)-1H-pyrazolo[3,4-d]pyrimidine-6-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylamine | HCID 674 | — |
| 反応物 | tert-Butyl 6-amino-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidine-1-carboxylate | HCID 22015534 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(2-Furyl)-1H-pyrazolo[3,4-d]pyrimidine-6-amine | HCID 22015500 | 70% |
反応手順
A solution of tert-butyl 6-amino-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidine-1-carboxylate (204 mg, 0.68 mmol) in MeOH (2 mL) was treated with dimethylamine in water (0.5 mL, 40%), refluxed for 1 h, cooled and the resulting solid filtered and washed with water to give the title compound (95 mg, 70%) as a cream solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087754B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-0aaf967e9712498692b57d3cf2a03587 |
| 出典メモ | uspto-grants-2006_08 |