Hydrochloric Acid → 3-pyrrolidin-3-yloxypyridine:hydrochloride

HRID 82940ノート

反応式

HRID 82940 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([O:7][CH:8]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]2)[CH:2]=1.[ClH:20]>ClCCl.O1CCOCC1>[ClH:20].[NH:10]1[CH2:11][CH2:12][CH:8]([O:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[CH2:9]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 10801570tert-Butyl 3-(pyridin-3-yloxy)pyrrolidine-1-carboxylate

生成物 1

HCID 534092893-pyrrolidin-3-yloxypyridine:hydrochloride収率 58%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

To a cooled solution of tert-butyl 3-(pyridin-3-yloxy)pyrrolidine-1-carboxylate (600 mg, 2.27 mmol; which may be prepared as described in Step 1) in dichloromethane (15 mL) was added dropwise HCl 4N in dioxane (11.1 mL). The solution was warmed to room temperature and stirred for 1 h. The solvent was evaporated under reduced pressure to give the title compound (263 mg, 58%) as a yellow wax.

後処理

  1. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-e01fe83dae154b26a679d904e99d3f51
出典データセット
uspto-grants-2014_09
特許番号
US08846711B2

反応ノート

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