化工社化工社 化学情報印刷レポート · 研究参考用
Water → 3-(6-Amino-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidine-1-ylmethyl)phenyl-2-thiophenesulphonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 2-Thiophenesulfonyl chloride | HCID 85518 | — |
| 反応物 | 1-(3-Aminobenzyl)-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidine-6-amine | HCID 22015499 | — |
| 生成物 | 3-(6-Amino-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidine-1-ylmethyl)phenyl-2-thiophenesulphonamide | HCID 86605127 | 22% |
反応手順
A solution of 1-(3-aminobenzyl)-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidine-6-amine (153 mg, 0.5 mmol) in pyridine (2 mL) was treated with 2-thiophenesulphonyl chloride (91 mg, 0.5 mmol), stirred at room temperature for 16 h, poured into water, extracted with EtOAc, dried (MgSO4), concentrated in vacuo and purified by chromatography (MeOH:DCM, 1:99) to give the title compound (49 mg, 22%) as a cream solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087754B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-df00543d4c174ad98bde971596d1cfc6 |
| 出典メモ | uspto-grants-2006_08 |