Hydrochloric Acid → 2-[(Azetidin-3-yloxy)methyl]-1,3-thiazole hydrochloride
反応式
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][O:7][CH:8]1[CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]1.[ClH:19]>C(OCC)C>[ClH:19].[NH:10]1[CH2:11][CH:8]([O:7][CH2:6][C:2]2[S:1][CH:5]=[CH:4][N:3]=2)[CH2:9]1参加物
4
実験手順
To a solution of tert-butyl 3-(1,3-thiazol-2-ylmethoxy)azetidine-1-carboxylate (193 mg, 0.71 mmol; which may be prepared as described in Step 2) dissolved in diethyl ether (2.6 mL) at room temperature was added HCl 2N in diethyl ether (7.1 mL). The reaction mixture was stirred for 1.5 h then concentrated to dryness. The resulting solid was triturated with diethyl ether, collected and dried to give the title compound (138 mg, quantitative) as a brown oil.
後処理
- concentrationthen concentrated to dryness
- customThe resulting solid was triturated with diethyl ether
- customcollected
- customdried
出典と根拠
- ORDレコード
- ord-d5ebb23cd03a4df6810aac6d2afaf3d9
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846711B2
反応ノート
読み込み中…