Hydrochloric Acid → 4-[(Azetidin-3-yloxy)methyl]pyridine dihydrochloride
反応式
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][O:8][CH:9]2[CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]2)=[CH:3][CH:2]=1.[ClH:20]>C(OCC)C>[ClH:20].[ClH:20].[NH:11]1[CH2:12][CH:9]([O:8][CH2:7][C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)[CH2:10]1参加物
4
実験手順
To a solution of tert-butyl 3-(pyridin-4-ylmethoxy)azetidine-1-carboxylate (313 mg, 1.18 mmol; which may be prepared as described in Step 3) in diethyl ether (4 mL) at 0° C. was added HCl 2N in diethyl ether (12 mL). The reaction mixture was stirred for 1 h then mixture was filtered. The resulting solid was rinsed with diethyl ether and collected to give the title compound as a white solid (155 mg, 65%).
後処理
- filtrationmixture was filtered
- washThe resulting solid was rinsed with diethyl ether
- customcollected
出典と根拠
- ORDレコード
- ord-613a8b4a2bbb4b1cb2cde095fc106f35
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846711B2
反応ノート
読み込み中…