化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Hydroxide → 2-(2',6'-Difluorophenyl)-1,8-naphthyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 1-(2,6-Difluorophenyl)ethan-1-one | HCID 83643 | — |
| 反応物 | 3-Pyridinecarboxaldehyde, 2-amino- | HCID 737633 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-(2',6'-Difluorophenyl)-1,8-naphthyridine | HCID 15790208 | 79% |
反応手順
2-Aminonicotinaldehyde (2.44 g, 20 mmol) and 2,6-difluoroacetophenone (3.28 g, 21 mmol) are dissolved in 20 ml of MeOH. The mixture is treated dropwise with 3 ml of 40% KOH and, after the exothermic reaction has subsided, it is poured onto water and the residue which is deposited is filtered off with suction. 3.8 g (79% yield) of the desired product are obtained. M.p. 100°-103° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723413 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-819df65591774363bb9b76f5effae47b |
| 出典メモ | uspto-grants-1998_03 |