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Potassium Hydroxide → 2-(2-Thiazolyl)-1,8-naphthyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 2-Acetylthiazole | HCID 520108 | — |
| 反応物 | 3-Pyridinecarboxaldehyde, 2-amino- | HCID 737633 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-(2-Thiazolyl)-1,8-naphthyridine | HCID 15790207 | 46.5% |
反応手順
2-Aminonicotinaldehyde (1.5 g, 12.3 mmol) and 2-acetylthiazole (1.64 g, 12.9 mmol) are dissolved in 12 ml of MeOH and the mixture is treated with 1.5 ml of 40% KOH. After 3 h, the reaction is complete and the mixture is poured onto water. The solid which is deposited is filtered off with suction, washed and dried. 1.22 g (yield 46%) of the desired product are obtained. M.p. 160°-165° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723413 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-6da8fccbc46d48d9b47085df7224e0c2 |
| 出典メモ | uspto-grants-1998_03 |