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(5-Methyl-3-phenyl-1,2-oxazol-4-yl)methanol → 2-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-5-nitro-pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (5-Methyl-3-phenyl-1,2-oxazol-4-yl)methanol | HCID 2776149 | — |
| 反応物 | HCID 178526703 | HCID 178526703 | — |
| 生成物 | 2-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-5-nitro-pyridine | HCID 68444760 | 37% |
反応手順
As described for example 4, (5-methyl-3-phenyl-isoxazol-4-yl)-methanol (200 mg, 1.06 mmol) was converted using 2-hydroxy-5-nitro-pyridine instead of 2-hydroxy-5-trifluoromethylpyridine to the title compound (SiO2, heptane:ethyl acetate:dichloromethane=80:0:20 to 50:30:20, 122 mg, 37%) which was obtained as a white solid. MS: m/e=312.2 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846719B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-034cd51963e7466d8b116b6ceaab4753 |
| 出典メモ | uspto-grants-2014_09 |