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2,4-Difluorobenzenesulfonyl Chloride → 1-[(2,4-Difluorophenyl)sulfonyl]-4-(1-piperazinyl)-1H-indole Hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,4-Difluorobenzenesulfonyl Chloride | HCID 2734273 | — |
| 反応物 | tert-Butyl 4-(1H-indol-4-yl)piperazine-1-carboxylate | HCID 22015386 | — |
| 生成物 | 1-[(2,4-Difluorophenyl)sulfonyl]-4-(1-piperazinyl)-1H-indole Hydrochloride | HCID 10201828 | — |
反応手順
The title compound was prepared from 4-(4-boc-piperazinyl)-indole and 2,4-di-fluorophenylsulfonylchloride according to Method 3: 1H NMR (270 MHz, DMSO-d6) δ 9.41 (br, 1 H), 8.24 (m, 1 H), 7.75 (m, 1 H), 7.58 (m, 1 H), 7.47–7.33 (m, 2 H), 7.23 (t, J=8 Hz, 1 H), 6.99 (d, J=5 Hz, 1 H), 6.70 (d, J -8 Hz, 1 H), 3.25 (m, 8 H). MS (ESI+) for m/z 378 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087750B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-d86cc93f907f48b381a9d7bc63bf7406 |
| 出典メモ | uspto-grants-2006_08 |