3,4-Dimethoxybenzenesulfonyl chloride → 1-[(3,4-Dimethoxyphenyl)sulfonyl]-4-(1-piperazinyl)-1H-indole Hydrochloride

HRID 8323

反応式

HRID 8323 の反応式
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:15]=2[CH:16]=[CH:17][NH:18]3)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[CH3:23][O:24][C:25]1[CH:26]=[C:27]([S:33]([Cl:36])(=[O:35])=[O:34])[CH:28]=[CH:29][C:30]=1[O:31][CH3:32]>>[ClH:36].[CH3:23][O:24][C:25]1[CH:26]=[C:27]([S:33]([N:18]2[C:19]3[C:15](=[C:14]([N:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)[CH:22]=[CH:21][CH:20]=3)[CH:16]=[CH:17]2)(=[O:34])=[O:35])[CH:28]=[CH:29][C:30]=1[O:31][CH3:32]

参加物

3

反応物 2

HCID 27341833,4-Dimethoxybenzenesulfonyl chlorideHCID 22015386tert-Butyl 4-(1H-indol-4-yl)piperazine-1-carboxylate

生成物 1

HCID 102034821-[(3,4-Dimethoxyphenyl)sulfonyl]-4-(1-piperazinyl)-1H-indole Hydrochloride

実験手順

The title compound was prepared from 4-(4-boc-piperazinyl)-indole and 3,4-dimethoxyphenylsulfonyl chloride according to Method 3: 1H NMR (270 MHz, DMSO-d6) δ 9.00 (br, 1 H), 7.82 (d, J=5 Hz, 1 H), 7.66 (d, J=8 Hz, 1 H), 7.57 (m, 1 H), 7.40 (d, J=3 Hz, 1 H), 7.24 (t, J=8 Hz, 1 H), 7.10 (d, J=8 Hz, 1 H), 6.90 (d, J=5 Hz, 1 H), 6.78 (d, J=8 Hz, 1 H), 3.78 (s, 6 H), 3.24 (m, 8 H); MS (ESI+) for m/z 402 (M+H)+.

出典と根拠

ORDレコード
ord-ac0698e88e6c456cbcd88503e97c7bdc
出典データセット
uspto-grants-2006_08
特許番号
US07087750B2

関連ノート

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