2,5-Dichlorobenzenesulfonyl chloride → 1-[(2,5-Dichlorophenyl)sulfonyl]-4-(1-piperazinyl)-1H-indole hydrochloride

HRID 8324

反応式

HRID 8324 の反応式
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:15]=2[CH:16]=[CH:17][NH:18]3)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=1[S:31](Cl)(=[O:33])=[O:32]>>[ClH:23].[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=1[S:31]([N:18]1[C:19]2[C:15](=[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[CH:22]=[CH:21][CH:20]=2)[CH:16]=[CH:17]1)(=[O:33])=[O:32]

参加物

3

反応物 2

HCID 794012,5-Dichlorobenzenesulfonyl chlorideHCID 22015386tert-Butyl 4-(1H-indol-4-yl)piperazine-1-carboxylate

生成物 1

HCID 220153711-[(2,5-Dichlorophenyl)sulfonyl]-4-(1-piperazinyl)-1H-indole hydrochloride

実験手順

The title compound was prepared according from 4-(4-boc-piperazinyl)-indole and 2,5-dichlorophenylsulfonyl chloride according to Method 3: 1H NMR (270 MHz, DMSO-d6) δ 9.09 (br, 1 H), 8.25 (d, J=3 Hz, 1 H), 7.91–7.81 (m, 2 H), 7.72 (d, J=8 Hz, 1 H), 7.36 (d, J 8 Hz, 1 H), 7.23 (t, J=8 Hz, 1 H), 6.98 (d, J 3 Hz, 1 H), 6.82 (d, J=8 Hz, H), 3.26(m,8 H).

出典と根拠

ORDレコード
ord-7fe7cc4c497e4dd289fbe25c44ed2869
出典データセット
uspto-grants-2006_08
特許番号
US07087750B2

関連ノート

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