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2-Methylpiperazine → 4-(3-Methyl-1-piperazinyl)-1-(2-methylbenzenesulfonyl)-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methylpiperazine | HCID 66057 | — |
| 反応物 | 4-Bromo-1-(2-methyl-benzenesulfonyl)-1H-indole | HCID 22015334 | — |
| 生成物 | 4-(3-Methyl-1-piperazinyl)-1-(2-methylbenzenesulfonyl)-1H-indole | HCID 22015381 | 38% |
反応手順
The compound was prepared from 4-bromo-1-(2-methyl-benzenesulfonyl)-1H-indole and 3-methylpiperazine according to Method 1 to give 110 mg (38%) of a white solid: 1HNMR (CD3OD) δ 7.92–6.82 (m, 9H), 3.64–3.39 (m, 5H), 3.12–3.03 (m, 1H), 2.92–2.83 (m, 1H), 2.47 (s, 3H), 1.40 (d, J=7 Hz, 3H); MS (ESI) 370.0 (M+H)+; Purity (HPLC) 94%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087750B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-5829e421f6d240ab92acd0e56ae1352b |
| 出典メモ | uspto-grants-2006_08 |