(R)-(-)-2-Amino-1-propanol → 6-[3-(4-Chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-((R)-2-hydroxy-1-methyl-ethyl)-nicotinamide

HRID 83372

反応式

HRID 83372 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([CH2:13][O:14][C:15]3[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][N:16]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[CH:4][CH:3]=1.[NH2:25][C@@H:26]([CH2:28][OH:29])[CH3:27]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12]([CH2:13][O:14][C:15]3[CH:23]=[CH:22][C:18]([C:19]([NH:25][C@H:26]([CH3:27])[CH2:28][OH:29])=[O:21])=[CH:17][N:16]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 80308(R)-(-)-2-Amino-1-propanolHCID 684428256-[3-(4-Chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid

生成物 1

HCID 426300486-[3-(4-Chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-((R)-2-hydroxy-1-methyl-ethyl)-nicotinamide収率 94%

実験手順

As described for example 254, 6-[3-(4-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid (100 mg, 0.29 mmol) was converted, using D-alaninol instead of 2-amino-2-methyl-1-propanol, to the title compound (100 mg, 94%) which was obtained as a white solid. MS: m/e=402.2 [M+H]+.

出典と根拠

ORDレコード
ord-aad7fd375f9940e28be4962a800a2dd1
出典データセット
uspto-grants-2014_09
特許番号
US08846719B2

関連ノート

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