化工社化工社 化学情報印刷レポート · 研究参考用
Chlorosuccinimide → 4-Fluoro-N-hydroxybenzimidoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chlorosuccinimide | HCID 31398 | — |
| 反応物 | Benzaldehyde, p-fluoro-, oxime | HCID 5372466 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Fluoro-N-hydroxybenzimidoyl chloride | HCID 5706360 | 100.2% |
反応手順
To a solution of (E)- and/or (Z)-4-fluoro-benzaldehyde oxime (100 g, 719 mmol) in DMF (500 mL) was added N-chlorosuccinimide (110 g, 791 mmol) portionwise keeping the temperature below 70° C. The reaction mixture was stirred at room temperature for 2.5 h and then extracted with tert-butyl methyl ether to afford the title compound (125 g, 100%) which was obtained as a yellow oil. MS: m/e=173.1 [M]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846719B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-3e0b07dfc2d0475b8709a2e52fbf575e |
| 出典メモ | uspto-grants-2014_09 |