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L-Alaninol → 6-[3-(4-Fluoro-phenyl)-isoxazol-4-ylmethoxy]-n-((s)-2-hydroxy-1-methyl-ethyl)-nicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-Alaninol | HCID 80307 | — |
| 反応物 | 6-[3-(4-Fluoro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester | HCID 68443977 | — |
| 生成物 | 6-[3-(4-Fluoro-phenyl)-isoxazol-4-ylmethoxy]-n-((s)-2-hydroxy-1-methyl-ethyl)-nicotinamide | HCID 42630544 | 59% |
反応手順
As described for example 325, 6-[3-(4-fluoro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester (60 mg, 0.18 mmol) was converted, using S-(+)-2-amino-1-propanol instead of rac-2-amino-1-propanol, to the title compound (28 mg, 59%) which was obtained as a white solid MS: m/e=370.3 [M−H]−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846719B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-86eee24f569d49758388980083c50d8d |
| 出典メモ | uspto-grants-2014_09 |