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Ethanolamine → 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]N-(2-hydroxy-ethyl)-nicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanolamine | HCID 700 | — |
| 反応物 | 6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid | HCID 66599213 | — |
| 反応物 | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid | HCID 68443769 | — |
| 生成物 | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]N-(2-hydroxy-ethyl)-nicotinamide | HCID 42630540 | 70% |
反応手順
As described for example 191, 6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid (100 mg, 0.3 mmol) was converted, instead of 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid, using ethanolamine instead of (1R,2R)-2-amino-cyclohexanol hydrochloride (1:1), to the title compound (79 mg, 70%) which was obtained as a white solid. MS: m/e=374.0 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846719B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-4e42414a2d05401097a871f611f3898b |
| 出典メモ | uspto-grants-2014_09 |