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1-Amino-2-propanol → 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-n-(2-hydroxy-propyl)-nicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Amino-2-propanol | HCID 4 | — |
| 反応物 | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid | HCID 68443769 | — |
| 生成物 | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-n-(2-hydroxy-propyl)-nicotinamide | HCID 42630541 | 43% |
反応手順
As described for example 346b, 6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid (200 mg, 0.6 mmol) was converted, using (rac)-1-amino-2-propanol instead of ethanolamine, to the title compound (100 mg, 43%) which was obtained as a colourless gum. MS: m/e=388.1 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846719B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-44fe2b6f6a484ae7b126349b18c1a432 |
| 出典メモ | uspto-grants-2014_09 |