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3-Pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester → 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester | HCID 66643758 | — |
| 反応物 | 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester | HCID 68444354 | — |
| 生成物 | 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid | HCID 68445257 | 96.3% |
反応手順
As described for example 358b, 6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (510 mg, 1.6 mmol), instead of 3-pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester, was converted to the title compound (458 mg, 94%) which was obtained as a white solid. MS: m/e=296.5 [M−H]−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846719B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-53e7dcb839ed45cc954071bc24ac5194 |
| 出典メモ | uspto-grants-2014_09 |