Dimethylformamide → 2-(4-((2'-chloro-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)methyl)-3-methyl-1H-pyrazol-1-yl)-nicotinic acid methyl ester

反応式

[C:25](=[O:26])([O-:27])[O-:28].[CH3:42][NH:43][CH:44]1[CH2:45][CH2:46][CH2:47][CH2:48][CH:49]1[NH:50][CH3:51].[CH3:52][N:53]([CH3:54])[CH:55]=[O:56].[Cl:1][c:2]1[cH:3][c:4]2[c:5]([s:24]1)[C:6]1([O:7][CH2:8][C:9]2([F:10])[F:11])[CH2:12][CH2:13][N:14]([CH2:17][c:18]2[c:19]([CH3:23])[n:20][nH:21][cH:22]2)[CH2:15][CH2:16]1.[Cs+:29].[Cs+:30].[I:31][c:32]1[n:33][cH:34][cH:35][cH:36][c:37]1[C:38](=[O:39])[O:40][CH3:41]>>[Cl:1][c:2]1[cH:3][c:4]2[c:5]([s:24]1)[C:6]1([O:7][CH2:8][C:9]2([F:10])[F:11])[CH2:12][CH2:13][N:14]([CH2:17][c:18]2[c:19]([CH3:23])[n:20][n:21](-[c:32]3[n:33][cH:34][cH:35][cH:36][c:37]3[C:38](=[O:39])[O:40][CH3:41])[cH:22]2)[CH2:15][CH2:16]1