Bromine → 2-Bromo-1-[3-(3-chloro-propoxy)-phenyl]-ethanone
反応式
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12](=[O:14])[CH3:13])[CH:9]=[CH:10][CH:11]=1.[Br:15]Br.C(=O)(O)[O-].[Na+]>CCOCC>[Br:15][CH2:13][C:12]([C:8]1[CH:9]=[CH:10][CH:11]=[C:6]([O:5][CH2:4][CH2:3][CH2:2][Cl:1])[CH:7]=1)=[O:14]参加物
5
実験手順
A solution of the product of Step A (2.1 g) in ether (11 mL) was treated with bromine (0.53 mL) and the mixture stirred for 26 hours. The mixture was poured into saturated sodium bicarbonate solution (50 mL) and the organic layer was separated. The aqueous layer was washed with a fresh portion of ether (50 mL) and the combined organic layers were washed with brine (50 mL), dried over magnesium sulfate, filtered, and evaporated to yield the title compound (2.8 g).
後処理
- customthe organic layer was separated
- washThe aqueous layer was washed with a fresh portion of ether (50 mL)
- washthe combined organic layers were washed with brine (50 mL)
- dry with materialdried over magnesium sulfate
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-dc9dcb2a36e24c068b009367510622ad
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07087757B2
反応ノート
読み込み中…