2,4-Dimethoxybenzylamine → HCID 71287769、化合物

HRID 83583ノート

反応式

HRID 83583 の反応式
CO[C:3]([C:5]1([C:8]([C:10]([O:12][CH3:13])=[O:11])=[CH2:9])[CH2:7][CH2:6]1)=[O:4].[CH3:14][O:15][C:16]1[CH:23]=[C:22]([O:24][CH3:25])[CH:21]=[CH:20][C:17]=1[CH2:18][NH2:19]>C1(C)C=CC=CC=1>[CH3:13][O:12][C:10]([CH:8]1[C:5]2([CH2:6][CH2:7]2)[C:3](=[O:4])[N:19]([CH2:18][C:17]2[CH:20]=[CH:21][C:22]([O:24][CH3:25])=[CH:23][C:16]=2[O:15][CH3:14])[CH2:9]1)=[O:11]

参加物

4

反応物 2

HCID 5972502,4-DimethoxybenzylamineHCID 866803911-(1-Methoxycarbonylvinyl)cyclopropanecarboxylic Acid Methyl Ester

生成物 1

HCID 71287769HCID 71287769、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of 1-(1-methoxycarbonylvinyl)cyclopropanecarboxylic acid methyl ester (720 mg) in toluene (3.6 ml) was added 2,4-dimethoxybenzylamine (587 μl) at room temperature, and then the mixture was stirred at reflux for 20 hours. This reaction mixture was concentrated under reduced pressure, the resulting residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=1/1) to give the titled compound (567 mg).

後処理

  1. temperatureat reflux for 20 hours
  2. concentrationThis reaction mixture was concentrated under reduced pressure
  3. customthe resulting residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=1/1)

出典と根拠

ORDレコード
ord-c90155ae579c439c8ebb8b7b6b0a8244
出典データセット
uspto-grants-2014_09
特許番号
US08846746B2

反応ノート

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