関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 1-Chloro-4-(chloromethyl)benzene | HCID 7723 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Methyl pyrrole-2-carboxylate | HCID 136930 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Methyl 1-(4-chlorobenzyl)-1H-pyrrole-2-carboxylate | HCID 50900833 | 86.5% |
反応手順
Methyl 1H-pyrrole-2-carboxylate (330 mg, 2.64 mmol) was dissolved in anhydrous DMF (8 mL). Solid K2CO3 (547 mg, 3.96 mmol) was added, followed by the addition of 1-chloro-4-(chloromethyl)benzene (638 mg, 3.96 mmol). The reaction was permitted to stir at 60° C. for 36 h, at which time the reaction was allowed to cool to rt. Water was added and the resulting precipitate was isolated over a filter, and dried under high vacuum overnight to give 570 mg of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08846684B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-d73f26653a394f2297a022d50ebf2dea |
|---|
| 出典メモ | uspto-grants-2014_09 |
|---|
