2-Amino-4-methylpyridine → 2-(4'-Chloropropoxy-3'-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine hydrobromide

HRID 8371

反応式

HRID 8371 の反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][CH2:14][Cl:15])=[C:7]([O:16][CH3:17])[CH:6]=1)=O.[NH2:18][C:19]1[CH:24]=[C:23]([CH3:25])[CH:22]=[CH:21][N:20]=1>C(O)C>[BrH:1].[Cl:15][CH2:14][CH2:13][CH2:12][O:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[N:18]=[C:19]3[CH:24]=[C:23]([CH3:25])[CH:22]=[CH:21][N:20]3[CH:2]=2)=[CH:6][C:7]=1[O:16][CH3:17]

参加物

4

反応物 2

HCID 15332-Amino-4-methylpyridineHCID 22015629alpha-Bromo-3'-methoxy-4'-chloropropoxyacetophenone

生成物 1

HCID 220155982-(4'-Chloropropoxy-3'-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine hydrobromide収率 70.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of the product of Step B (1.44 g) and 2-amino-4-picoline (0.486 g) in ethanol (6 mL) was heated at 73° C. for 1 hour. The reaction mixture was cooled to ambient temperature and evaporated to a yellow solid. The solid was stirred with 25 mL of dichloromethane for approximately 10 minutes. The mixture was filtered and the solid product collected to yield the title compound (1.3 g).

後処理

  1. customevaporated to a yellow solid
  2. filtrationThe mixture was filtered
  3. customthe solid product collected

出典と根拠

ORDレコード
ord-979a976b36f74db790007f7dd4f936ca
出典データセット
uspto-grants-2006_08
特許番号
US07087757B2

関連ノート

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