Dichloromethane → 1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarbonyl chloride

関与物質

役割	名称	HCID	仕込み量
反応物	Dichloromethane	HCID 6344	—
反応物	Thionyl Chloride	HCID 24386	—
反応物	1-(1,3-Dioxaindan-5-yl)cyclopropane-1-carboxylic acid	HCID 14349608	—
溶媒	Dimethylformamide	HCID 6228	—
生成物	1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarbonyl chloride	HCID 59129154	—

反応手順

To an oven-dried round bottom flask containing 1-(benzo[d][1,3]dioxol-5-yl)-cyclopropanecarboxylic acid (A-8) (618 mg, 3.0 mmol) and CH2Cl2 (3 mL) was added thionyl chloride (1.07 g, 9.0 mmol) and N,N-dimethylformamide (0.1 mL). The reaction mixture was stirred at ambient temperature under an Ar atmosphere until the gas evolution ceased (2-3 h). The excess thionyl chloride was removed under vacuum and the resulting residue dissolved in CH2Cl2 (3 mL). The mixture was used without further manipulation.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08846753B2
出典データセット	uspto-grants-2014_09
ORD ID	ord-b9a424f48cb942e69d8f2d0e689c65ef
出典メモ	uspto-grants-2014_09