Hydrochloric Acid → 2-(4-Aminophenoxy)acetic acid hydrochloride

HRID 83774

反応式

HRID 83774 の反応式
C([O:3][C:4](=[O:17])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13]C(=O)C)=[CH:9][CH:8]=1)C.[ClH:18]>>[ClH:18].[NH2:13][C:10]1[CH:9]=[CH:8][C:7]([O:6][CH2:5][C:4]([OH:17])=[O:3])=[CH:12][CH:11]=1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 309738Ethyl 2-(4-acetamidophenoxy)acetate

生成物 1

HCID 668114882-(4-Aminophenoxy)acetic acid hydrochloride収率 77.6%

反応条件

温度
10 °C

実験手順

(4-Acetylamino-phenoxy)-acetic acid ethyl ester 1 (375 grams, 1.582 mmol), in concentrated Hydrochloric acid (9.36 liters) was refluxed for 12 Hours. Excess concentrated Hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 2 (250 g, 77.6%) as a wheat colored powder.

後処理

  1. distillationExcess concentrated Hydrochloric acid was distilled off in vacuum
  2. filtrationfiltered hot
  3. filtrationfiltered
  4. customdried

出典と根拠

ORDレコード
ord-9069b2e2cf384531903fee23e517008c
出典データセット
uspto-grants-2014_09
特許番号
US08846845B2

関連ノート

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