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4-Nitrophenol → Methyl 2-(4-nitrophenoxy)propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Nitrophenol | HCID 980 | — |
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Methyl 2-chloropropionate | HCID 28659 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | Methyl 2-(4-nitrophenoxy)propanoate | HCID 4501947 | 31% |
反応手順
To a mixture of 4-nitrophenol (200 grm, 1.439 mol), anhydrous K2CO3 (800 grm, 5.789 mol) and sodium iodide (10 g, 66.7 mmol) in anhydrous acetone (2.75 L) was added methyl 2-chloropropionate (264 g, 2.154 mol) and refluxed for 20 hours. Acetone was distilled off and water (3 L) was added. Crude 14 was filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:5) to give pure 14 (100 g, 31%) as a white fluffy powder with a m.p between 83-84° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846845B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-8d8c1ad925fa435f8b7bbb7966f51d1b |
| 出典メモ | uspto-grants-2014_09 |