Methyl (4-nitrophenoxy)acetate → (4-Nitrophenoxy)acetic acid

HRID 83794

反応式

HRID 83794 の反応式
[N+:1]([C:4]1[CH:15]=[CH:14][C:7]([O:8][CH2:9][C:10]([O:12]C)=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2]>Cl>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([O:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:14][CH:15]=1)([O-:3])=[O:2]

参加物

3

反応物 1

HCID 700522Methyl (4-nitrophenoxy)acetate

生成物 1

HCID 15720(4-Nitrophenoxy)acetic acid収率 92.1%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

Methyl (4-nitrophenoxy)acetate 7 (100 g, 474 mmol) was refluxed in conc. HCl (1 L) for 8 hours. The reaction mass was cooled to room temperature and crude 22 was filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:5) to give pure 22 (86 g, 92.1%) as a white shining powder with an m.p. between 186-188.5° C.

後処理

  1. filtrationcrude 22 was filtered
  2. customdried
  3. customrecrystallised from a mixture of ethyl acetate:hexane (1:5)

出典と根拠

ORDレコード
ord-42264802e0824e209a60887ea512f6f7
出典データセット
uspto-grants-2014_09
特許番号
US08846845B2

関連ノート

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