Piperidine → 4-Piperidinylbut-1-ene
反応式
Br[CH2:2][CH2:3][CH:4]=[CH2:5].[NH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1>>[N:6]1([CH2:7][CH2:8][CH:9]=[CH2:10])[CH2:11][CH2:5][CH2:4][CH2:3][CH2:2]1参加物
3
実験手順
A mixture of 1-bromo-3-butene (1.35 g, 10 mmol) and piperidine (1.70 g, 20 mmol) neat was refluxed under nitrogen atmosphere for 3 h. Cooled to RT, filtered and dissolved into ethyl ether (40 mL). Then solution was washed with water (2×30 mL) and dried over anhydrous Na2SO4, filtered and evaporated to dryness to yield 1.3 g (74.15%) oily 1-piperidyl-3-butene.
後処理
- temperatureneat was refluxed under nitrogen atmosphere for 3 h
- filtrationfiltered
- dissolutiondissolved into ethyl ether (40 mL)
- washThen solution was washed with water (2×30 mL)
- dry with materialdried over anhydrous Na2SO4
- filtrationfiltered
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-2927bd8c3c9846bbb36c39855a81a50c
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07087757B2
反応ノート
読み込み中…