4'-Hydroxyacetophenone → 2-Bromo-1-(4-hydroxyphenyl)ethanone
反応式
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[Br:11]Br.C(=O)(O)[O-].[Na+]>CCOCC>[CH:5]1[C:4]([C:1]([CH2:2][Br:11])=[O:3])=[CH:9][CH:8]=[C:7]([OH:10])[CH:6]=1参加物
5
実験手順
4-Acetylphenol (20 g) in ether (200 mL) was treated with bromine (6.8 mL) and stirred at ambient temperature for 18 hours. The solution was poured into saturated sodium bicarbonate, stirred for 30 minutes and the organic layer separated. The organic portion was washed with saturated sodium bicarbonate, dried over magnesium sulfate, filtered and evaporated to afford the title compound (30 g).
後処理
- stirringstirred for 30 minutes
- customthe organic layer separated
- washThe organic portion was washed with saturated sodium bicarbonate
- dry with materialdried over magnesium sulfate
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-c56bedb66ea340c2b3e2c3252be8914e
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07087757B2
反応ノート
読み込み中…