4'-Hydroxyacetophenone → 2-Bromo-1-(4-hydroxyphenyl)ethanone

HRID 8383

反応式

HRID 8383 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[Br:11]Br.C(=O)(O)[O-].[Na+]>CCOCC>[CH:5]1[C:4]([C:1]([CH2:2][Br:11])=[O:3])=[CH:9][CH:8]=[C:7]([OH:10])[CH:6]=1

参加物

5

反応物 3

HCID 74694'-HydroxyacetophenoneHCID 24408BromineHCID 516892Sodium Bicarbonate

生成物 1

HCID 49642-Bromo-1-(4-hydroxyphenyl)ethanone

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

4-Acetylphenol (20 g) in ether (200 mL) was treated with bromine (6.8 mL) and stirred at ambient temperature for 18 hours. The solution was poured into saturated sodium bicarbonate, stirred for 30 minutes and the organic layer separated. The organic portion was washed with saturated sodium bicarbonate, dried over magnesium sulfate, filtered and evaporated to afford the title compound (30 g).

後処理

  1. stirringstirred for 30 minutes
  2. customthe organic layer separated
  3. washThe organic portion was washed with saturated sodium bicarbonate
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-c56bedb66ea340c2b3e2c3252be8914e
出典データセット
uspto-grants-2006_08
特許番号
US07087757B2

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