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Epichlorohydrin → 7-(2,3-Epoxypropoxy)-2,2-dimethyl-4-phenylchroman
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Epichlorohydrin | HCID 7835 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2,2-Dimethyl-7-hydroxy-4-phenylchroman | HCID 20570531 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 7-(2,3-Epoxypropoxy)-2,2-dimethyl-4-phenylchroman | HCID 23330756 | 95% |
反応手順
A mixture of 7-hydroxy-2,2-dimethyl-4-phenylchroman (11.8g, .046 mole), anhydrous potassium carbonate (11.7g, 0.093 mole), epichlorohydrin (50ml) and dry acetone (50ml) was stirred and boiled under reflux for 6 hours, then cooled and filtered. The filtrate was evaporated in vacuo and the residual brown oil dissolved in ether, washed with water and dried (magnesium sulphate). Removal of the solvent gave 7-(2,3-epoxypropoxy)-2,2-dimethyl-4-phenylchroman as a pale brown solid (13.56g, 95%), m.p. 82°-85°, after crystallization from ethanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04093631 |
| 出典データセット | uspto-grants-1978_06 |
| ORD ID | ord-635f87242d28449a9321f53824cbd9d3 |
| 出典メモ | uspto-grants-1978_06 |