2-Chloro-5,6-dimethoxy-1H-benzo[d]imidazole → HCID 70619004、化合物

HRID 838970ノート

反応式

HRID 838970 の反応式
[Cl:1][C:2]1[NH:3][C:4]2[CH:10]=[C:9]([O:11][CH3:12])[C:8]([O:13][CH3:14])=[CH:7][C:5]=2[N:6]=1.[CH3:15][CH:16]([CH3:27])[CH2:17][CH2:18][C:19]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)=[O:20]>COCCO>[ClH:1].[CH3:12][O:11][C:9]1[C:8]([O:13][CH3:14])=[CH:7][C:5]2[N:6]=[C:2]([N:24]3[CH2:25][CH2:26][N:21]([C:19](=[O:20])[CH2:18][CH2:17][CH:16]([CH3:15])[CH3:27])[CH2:22][CH2:23]3)[NH:3][C:4]=2[CH:10]=1

参加物

4

反応物 2

HCID 203255242-Chloro-5,6-dimethoxy-1H-benzo[d]imidazoleHCID 205965884-Methyl-1-(piperazin-1-yl)pentan-1-one

生成物 1

HCID 70619004HCID 70619004、化合物

試薬・触媒・溶媒 1

HCID 80192-Methoxyethanol溶媒

実験手順

By the method of Example I, 2.00 g 2-chloro-5,6-dimethoxy benzimidazole and 4.00 g N-(4-methyl valeroyl) piperazine were reacted in 15 ml. 2-methoxy ethanol to give the desired product as a base; which was converted to the hydrochloride with HCl in isopropyl alcohol. Yield: 3.31 g (89%) mp 255°-257° C.

出典と根拠

ORDレコード
ord-6ba4383731b941078150a93689311a6b
出典データセット
uspto-grants-1978_06
特許番号
US04093726

反応ノート

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